Can High Cholesterol Cause Headaches

The Potential Link Between High Cholesterol & Headaches

High cholesterol is a common health condition that affects millions of people worldwide. But can having high cholesterol levels also lead to headaches? In this in-depth article, we’ll examine the link between high cholesterol and headaches, looking at the latest scientific research and expert perspectives.

Headaches are one of the most common medical complaints, affecting people of all ages and backgrounds. Tension headaches and migraines can severely impact quality of life and productivity. As such, understanding the various causes and triggers of headaches is important for effective treatment and prevention.

In recent years, some studies have suggested a potential association between high cholesterol and headaches. High cholesterol, especially LDL (“bad cholesterol”), can cause plaque buildup in blood vessels over time. This may restrict blood flow to the brain, theoretically triggering vascular headaches like migraines.

However, the evidence so far has been limited and inconsistent. In this article, we’ll analyze the current research linking high cholesterol and headaches. We’ll also provide tips on managing high cholesterol levels and headache symptoms.

How Can High Cholesterol Cause Headaches?

Here are some potential reasons that have been proposed for how high cholesterol could contribute to headaches:

Narrowing of blood vessels

Cholesterol plaque buildup in cerebral arteries may restrict blood flow and oxygen supply to the brain. This vasoconstriction and reduced oxygen could trigger migraines and other vascular headaches.


Elevated LDL cholesterol can lead to inflammation in blood vessel linings and tissues. This inflammation may activate pain pathways and increase sensitivity, contributing to migraine pain.

Disrupted cellular metabolism

Abnormal cholesterol levels could potentially affect mitochondria and cellular energy production in the brain. This may reduce the brain’s threshold for migraine triggers.

Increased platelet aggregation

High cholesterol can make platelets stickier, leading to clot formation. These microclots may obstruct blood flow and oxygen delivery, triggering headaches.

Ceramide accumulation

LDL cholesterol upregulates ceramide production. Ceramides are pro-inflammatory lipids that may accumulate in migraineurs’ brains and be linked to migraine aura and pain.

Endothelial dysfunction

Dysfunctional endothelium (blood vessel lining) is linked to vascular diseases and may impair vasodilation. This could limit blood flow to the brain and trigger migraines.

Effect on serotonin

Cholesterol may inhibit serotonin receptors. Since serotonin is linked to migraine pathogenesis, this may lower the migraine threshold.

However, these mechanisms are still speculative. More research is needed to definitively prove if and how high cholesterol can directly instigate headaches in some patients. The link is likely complex and multifactorial.

What Is High Cholesterol?

High cholesterol refers to elevated levels of total cholesterol, LDL “bad” cholesterol, and triglycerides in the blood.

Some key points about high cholesterol:

  • Total cholesterol levels above 200 mg/dL are considered elevated. LDL cholesterol above 100 mg/dL is considered high.
  • High cholesterol does not usually have outward symptoms. The only way to diagnose it is through a blood test.
  • Genetic factors can predispose people to high cholesterol, but lifestyle factors like diet, weight, and exercise also play a major role.
  • High cholesterol can build up on artery walls in the form of plaque. This atherosclerosis narrows arteries and increases the risk of heart attack and stroke.
  • Key risk factors for high cholesterol include obesity, physical inactivity, smoking, diabetes, high blood pressure, poor diet, family history, older age.
  • High cholesterol can often be treated effectively through lifestyle changes like diet, exercise, and quitting smoking. But medications like statins may also be prescribed.
  • Managing high cholesterol is important to reduce cardiovascular disease risk. However, there is limited evidence directly linking it to headaches.
  • Adults should get a fasting lipoprotein profile blood test at least once every 4-6 years to screen for high cholesterol.

So in summary, high cholesterol is elevated blood lipids that increase the risk for various diseases. However, its direct relationship to headaches needs more research.

High cholesterol in blood
High cholesterol in the blood

The Link Between High Cholesterol and Headaches

Here’s what the latest scientific research says about the purported connection between cholesterol levels and headaches:

Observational Studies

Several observational studies have found an association between high total cholesterol, LDL cholesterol, and triglycerides and increased headache frequency or intensity.

For example, a 2015 study published in the European Journal of Neurology followed 9,141 people for over 20 years. They found that participants with total cholesterol levels above 5.0 mmol/L had a 37% higher risk of frequent tension-type headaches.

Another study published in Cephalalgia in 2013 followed over 15,000 people in Norway for 11 years. They found a positive correlation between chronic headaches and high non-fasting total cholesterol levels.

However, due to the observational nature of these studies, they cannot prove cause and effect. Confounding factors like obesity were not fully accounted for.

Clinical Trials

A few small clinical trials have tested whether lowering cholesterol levels with statin medications can improve headaches. The results have been mixed.

A 2016 double-blind trial published in European Neurology gave 37 patients with migraine either atorvastatin or a placebo. After 12 weeks, the atorvastatin group had significantly fewer migraine attacks per month.

However, other similar trials found no difference in headache frequency or severity when comparing statins to placebos. More large-scale studies are still needed.

Expert Perspectives

Given the limited and contradictory research findings so far, what do experts make of the potential link between high cholesterol and headaches?

The American Migraine Foundation states that there is currently “no definitive evidence” that high cholesterol causes migraines or other headache disorders. They do not recommend routine cholesterol screening specifically for migraine patients.

The American Headache Society agrees that more research is needed before concluding there is a causal relationship between cholesterol and headaches. They say elevated cholesterol may potentially be a risk factor for chronic migraines.

The Migraine Research Foundation also says there is “insufficient and contradictory evidence” that high cholesterol triggers migraines. They encourage maintaining normal cholesterol levels through diet as part of an overall healthy lifestyle.

Overall, most experts agree that the evidence is still preliminary and inconclusive. While a correlation may exist, there is no proof that high cholesterol directly results in chronic headaches for most patients.

Difference between Headache And Migraine Pain?

Here is a table comparing headaches vs. migraines:

Feature Headache Migraine
Pain location Can occur anywhere in the head Usually one side of the head (unilateral)
Pain type Dull, squeezing Throbbing, pounding
Pain severity Mild to moderate Moderate to severe
Duration 30 minutes to several hours 4-72 hours if untreated
Frequency Episodic or chronic Episodic
Symptoms None of nausea Nausea, vomiting, sensitivity to light/sound
Triggers Stress, fatigue, eyestrain Hormonal changes, stress, some foods
Disability Mild Significantly limits activity
Medications OTC pain relievers Prescription abortive and preventive medications
Other disorders May co-occur with migraines Linked to stroke, depression, anxiety

Migraines differ from common headaches in several ways – they are more severe, last longer, have additional symptoms, and are specifically triggered. Migraines are also considered a neurological disease rather than just a symptom.

Treatment Of High Cholesterol And Headaches

Here is a table comparing treatment approaches for high cholesterol vs. headaches:

Treatment High Cholesterol Headaches
Lifestyle changes
  • Heart healthy diet
  • Exercise regularly
  • Smoking cessation
  • Weight management
  • Identify and avoid triggers
  • Manage stress
  • Improved sleep habits
  • Hydration
  • Healthy eating
  • Statins
  • Ezetimibe
  • Bile acid sequestrants
  • PCSK9 inhibitors
  • OTC pain relievers (acetaminophen, NSAIDs)
  • Migraine-specific abortive treatments (triptans, ergots)
  • Migraine preventive therapies (beta blockers, antidepressants)
Alternative therapies
  • Phytosterol/stanol supplements
  • Garlic, niacin, fiber, soy
  • Acupuncture
  • Massage
  • Yoga, meditation
  • Biofeedback
Medical procedures
  • LDL apheresis (severe cases)
  • Nerve blocks
  • Botulinum toxin injections
  • Fish oil
  • Soluble fiber
  • Riboflavin
  • Magnesium
  • Coenzyme Q10
Follow up
  • Regular cholesterol blood tests  Cardiovascular monitoring
  • Headache diary
  • Neurology visits for persistent migraines

In summary, high cholesterol and headaches have some overlapping lifestyle treatment approaches but generally require different medications and procedures targeted to the specific condition. A combination approach is best.

Complications Or Risk Of High Cholesterol And Headaches

Here is a table comparing the potential complications and risks associated with high cholesterol vs. headaches:

Complications/Risks High Cholesterol Headaches
Cardiovascular disease Increased risk of atherosclerosis, heart attack, stroke No direct increase in risk
Brain/Cognition No direct effect Migraines may impact cognitive function during and between attacks
Mental Health No direct effect Headache disorders associated with anxiety and depression
Vision Changes No direct effect Migraines can cause visual disturbances, aura
Sleep Disruption No direct effect Headaches and migraines may cause insomnia
GI Issues No direct effect Migraines associated with nausea, vomiting
Kidney Problems No direct effect Dehydration from nausea/vomiting may impact the kidneys
Medication Overuse No effect Overuse of pain meds can cause medication overuse headache
Hormonal Changes No direct effect Headaches in women linked to hormonal fluctuations
Pregnancy Issues No direct effect Migraines can worsen during pregnancy for some
Serotonin Imbalance No direct effect Low serotonin levels may trigger migraines
Neck/Nerve Pain No direct effect Headaches associated with neck tension, nerve pain

High cholesterol primarily increases the risk of cardiovascular problems, while headaches and migraines can disrupt multiple aspects of health and quality of life.

Diagnosis Of High Cholesterol and Headaches

Here is a comparison of the diagnosis methods for high cholesterol versus headaches:

Diagnosis High Cholesterol Headaches
Medical history
  • Family history of high cholesterol  Existing health conditions
  • Medications
  • Diet and lifestyle habits
  • Family history of headaches
  • Headache frequency, severity, duration
  • Triggers, alleviating factors
  • Response to prior treatments
Physical exam
  • Vital signs
  • Signs of atherosclerosis
  • Neurological exam
  • Neck exam
  • Blood pressure
Lab tests
  • Cholesterol blood test (lipoprotein profile) LDL, HDL, total cholesterol, triglycerides
  • None definitive may check: Blood tests to rule out other causes MRI or CT scan if needed
Diagnostic criteria
  • Elevated total and LDL cholesterol levels per guidelines
  • Features of headache patterns
  • Diagnostic criteria for migraine, cluster headache, etc.
  • Chest pain, fatigue (advanced disease)
  • Headache diary tracking frequency, symptoms, triggers, etc.
Risk calculators
  • ASCVD risk calculator
  • Framingham risk score
  • No equivalent risk scores

In summary, high cholesterol is definitively diagnosed via blood tests, while headaches rely more on clinical criteria and patient reports of patterns and triggers.


Frequently Asked Questions

Are headaches a symptom of high cholesterol?

There is some limited evidence that high cholesterol may be associated with an increase in certain headaches like migraines. However, most experts agree headaches are not a direct symptomatic result of high cholesterol for most people. More research is needed on the potential link.

Should I have my cholesterol tested if I have frequent headaches?

There is likely no harm in having your cholesterol checked as part of routine screening for cardiovascular health. However, experts do not specifically recommend cholesterol testing solely for headaches at this point. Discuss your headaches and medical history with your doctor.

If I lower my cholesterol, will it get rid of my headaches?

There is no strong evidence that lowering cholesterol with medication or dietary changes will reliably reduce headaches in most patients. However, maintaining healthy cholesterol levels is still smart for overall health. Discuss the best headache treatment options with your neurologist.

Are statin medications recommended for treating headaches?

There is limited and contradictory evidence on whether statin cholesterol medications prevent headaches. Most experts do not currently recommend statins specifically for headache relief. Statins may be prescribed primarily for high cholesterol.

What lifestyle changes can help lower cholesterol and headaches?

Healthy lifestyle measures like diet, exercise, stress management, sufficient sleep, avoiding smoking, and limiting alcohol may help both cholesterol levels and headaches. But consult your doctor about medications if needed.

Last Words

While a few observational studies show an association between high cholesterol and headaches, there is currently no definitive evidence proving a direct causal relationship. More large-scale clinical trials are needed. For now, experts do not recommend routine cholesterol screening or statin medications specifically for headache disorders.

However, maintaining optimal cholesterol levels through diet and exercise is still smart for overall health. Likewise, properly managing headaches through trigger avoidance, medications, and lifestyle measures is important for improving quality of life.

Work closely with your doctors to develop comprehensive treatment plans for any cholesterol issues or frequent headaches. Keep tracking your symptoms and get regular checkups. While more research is still needed, being proactive about prevention is wise.


My name is Selina, a medical specialist blogger helping people access treatment for 5+ years. Although blogging awhile, only recently deeply engaged. This past year my most productive, providing hospital reviews and info on symptoms, diagnoses and diseases. Also offer guidelines to help readers navigate healthcare. Goal to continue increased content pace to assist many. Aim to facilitate treatment and empower advocacy through writing.

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